NCT06960148

Dentinal Hypersensitivity Reduction Efficacy Study

Clinical Investigation of the Dentinal Hypersensitivity Reduction Efficacy of CSPR Toothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste Immediately Following Direct Topical Application of the Product and After Subsequent Brushing With the Product for Eight Weeks.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 95 (actual)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Assess the clinical efficacy of CSPR Toothpaste containing 8% arginine to provide dentinal hypersensitivity relief

Detailed description

The objective of this study is to assess the clinical efficacy of CSPR Toothpaste containing 8% arginine to provide dentinal hypersensitivity relief (tactile and air blast) at instant, 3 days, 4 weeks and 8 weeks in comparison to Colgate Cavity Protection Toothpaste over an eight-week period.

Conditions

• Sensitivity, Tooth

Interventions

Type	Name	Description
DRUG	CSPR Toothpaste	a commercially available 8% arginine toothpaste
DRUG	Colgate Dental Cream Toothpaste	a commercially available fluoride toothpaste

Timeline

• Start date: 2025-03-04
• Primary completion: 2025-05-13
• Completion: 2025-05-13
• First posted: 2025-05-07
• Last updated: 2026-03-19

Locations

1 site across 1 country: China