NCT06954103

Mechanisms And Prognosis of Stroke-Heart Syndrome

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 658 (estimated)
• Sponsor: Chensheng Pan · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes in stroke patients. However, the underlying mechanisms remain unclear, and there are currently no effective prevention or treatment strategies. This study aims to elucidate the neuro-humoral mechanisms of stroke-heart syndrome through multimodal imaging and multi-omics blood analysis. Additionally, it seeks to observe the progression of stroke-heart syndrome and its impact on functional outcomes, cognitive abilities, and emotional issues post-stroke. The research is expected to uncover novel blood biomarkers and brain network mechanisms associated with stroke-heart syndrome, providing potential targets and theoretical foundations for pharmacological treatments or physical interventions. Furthermore, it aims to establish a risk early-warning system for major cardiovascular complications post-stroke, enabling early identification, early intervention, and integrated brain-heart management to improve clinical outcomes for stroke patients.

Conditions

• Stroke
• Myocardial Injury
• Heart Failure
• Acute Coronary Syndromes
• Arrhythmia
• Sudden Cardiac Death
• Takotsubo Syndrome
• Heart Rate Variability

Timeline

• Start date: 2025-03-01
• Primary completion: 2028-03-01
• Completion: 2028-04-01
• First posted: 2025-05-01
• Last updated: 2025-05-01

Locations

1 site across 1 country: China