NCT06953557

Evaluation of the Salivary-free Amino Acids Levels (Glycine , Proline , Lysine , and Alanine ) With Caries Activity

Evaluation of the Salivary-free Amino Acids Levels With Caries Activity

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Al-Mustansiriyah University · Academic / Other
• Sex: All
• Age: 8 Years – 10 Years
• Healthy volunteers: Accepted

Summary

This study will be aimed to investigated the correlation between levels of salivary amino acids (glycine , proline , lysine , alanine ) in the saliva of healthy children with and without active carious lesions and to estimate the predictive capacity of caries susceptibility

Detailed description

80 healthy children (8-10 years old) will be recruited from primary schools of Baghdad city/ Iraq, will be classified according to their level of caries activity (high caries activity, n = 40; negative caries activity, n = 40). Total stimulated and unstimulated saliva will be collected to estimate the caries activity by using the Snyder test, and Amino acid analysis of the saliva will be performed by reversed phase - high performance liquid chromatography (RP-HPLC), respectively.

Conditions

• Dental Caries

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity	The investigators will measure Salivary-free amino acids by using reverse phase high performance liquid chromatography

Timeline

• Start date: 2025-04-30
• Primary completion: 2025-05-30
• Completion: 2025-06-30
• First posted: 2025-05-01
• Last updated: 2025-05-01