NCT06949592

Oral Bioavailability of the Phenolic Compounds in a Melissa Supplement

Evaluation of Oral Bioavailability of the Phenolic Compounds in a Melissa Supplement: Double-blind, Randomized, Crossover Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Fytexia · Industry
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to identify phenolic compound biomarkers of the intake of a mixture of Melissa officinalis extract, acerola extract and vitamin B5. This will be done through the study of their bioavailability and nutrikinetics by measuring their plasma concentrations and urinary excretion over 24h by means of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The study follows a cross-over, double-blind, randomized and placebo control design on 10 healthy subjects

Conditions

• Nutrition, Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Intake of 400 mg placebo (maltodextrin; encapsulated) in the morning (09:00)
DIETARY_SUPPLEMENT	M_ML	Intake of 400 mg M\_ML (encapsulated) in the morning (09:00)
DIETARY_SUPPLEMENT	M_ML	Intake of 400 mg M\_ML (encapsulated) in the evening (19:00)

Timeline

• Start date: 2025-04-30
• Primary completion: 2025-06-12
• Completion: 2025-06-12
• First posted: 2025-04-29
• Last updated: 2025-06-15

Locations

1 site across 1 country: Spain