NCT06929572

Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 24 Hours
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the impact of an autologous umbilical cord patch for dural closure on the repair of open neural tube defect. The outcomes will evaluate successful defect closure, creation of a more capacious spinal canal, and reduction in inflammatory tissue response versus historical controls.

Conditions

• Spina Bifida

Interventions

Type	Name	Description
PROCEDURE	Autologous umbilical cord patch	Surgery will occur from birth to 24 hours of age. The autologous umbilical cord patch is harvested at time of delivery and immediately processed in a sterile setting in order to create a dural patch as a spinal cord cover to close the developmental defect within a few hours after birth.

Timeline

• Start date: 2025-08-05
• Primary completion: 2028-07-01
• Completion: 2033-01-01
• First posted: 2025-04-16
• Last updated: 2025-09-12

Locations

1 site across 1 country: United States