NCT06915688

A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations

Comparison of Clinical Cure Rate of Doxycycline and Levofloxacin in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 188 (estimated)
• Sponsor: Amina Aslam · Other Government
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days. The aim is to compare how effective each antibiotic is in improving symptoms after 2 days of treatment.

Detailed description

This randomized controlled trial will evaluate the effectiveness of two antibiotics-doxycycline (a tetracycline) and levofloxacin (a fluoroquinolone)-in the treatment of acute exacerbations of chronic obstructive pulmonary disease. Participants will be assigned to one of the two treatment groups and will receive either doxycycline 100 mg twice daily or levofloxacin 500 mg once daily for 5 days. The primary outcome is clinical cure. This will be evaluated 2 days after completion of antibiotic therapy, based on symptom resolution and laboratory markers.

Conditions

• COPD

Interventions

Type	Name	Description
DRUG	Doxycycline	Doxycycline will be given to COPD group 1
DRUG	Levofloxacin	Levofloxacin given to copd patients

Timeline

• Start date: 2025-04-15
• Primary completion: 2025-07-28
• Completion: 2025-07-31
• First posted: 2025-04-08
• Last updated: 2025-04-08

Locations

1 site across 1 country: Pakistan