NCT06910683

Technology dRiven Enhancement to Engage & Connect

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Weill Medical College of Cornell University · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate whether an intervention that includes remotely delivered therapy sessions and a digital mental health app, compared to only remotely delivered therapy reduces late-life depression

Detailed description

Depression in mid- and late-life is characterized with reduced functions of the reward system. The investigators designed a psychotherapy that aims to improve reward functions through engagement in pleasurable activities and in turn reduce depression. Prior work has shown that this therapy is acceptable and reduces depression. This study examines whether a hybrid intervention that combines clinician remotely-delivered psychotherapy, and a novel app named TREE-Connect, reduces late life depression. This TREE-Connect app uses a machine learning algorithm to promote adherence to therapy (completion of therapeutic homework) in late-life depression and increase cost-effectiveness and reach of treatment to older adults. This randomized controlled trials will test whether the hybrid intervention (clinician-delivered psychotherapy + app), compared to a condition that includes solely clinician-delivered therapy is acceptable and reduces late-life depression.

Conditions

• Depression

Interventions

Type	Name	Description
BEHAVIORAL	TREE-Connect	TREE-Connect is a mental health app that aims to increase engagement in rewarding activities
BEHAVIORAL	Clinician-delivered psychotherapy	Clinician-delivered psychotherapy is delivered remotely and aimed to increase engagement in rewarding activities

Timeline

• Start date: 2027-03-01
• Primary completion: 2029-03-01
• Completion: 2029-03-01
• First posted: 2025-04-04
• Last updated: 2026-03-24

Locations

1 site across 1 country: United States