NCT06909305

Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis

Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis: A Randomized Prospective Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to compare intraarticular ozone injection, prolotherapy, or dexmedetomidine effectiveness in knee osteoarthritis patients.

Detailed description

Osteoarthritis (OA) is a heterogeneous group of disorders of different etiologies with similar biological, morphological, and clinical manifestations and outcomes. The intraarticular injection has been recommended to alleviate the pain in the knee joint. Ozone therapy has long been used in the management of OA. Furthermore, it has been shown to not cause a significant inflammation process or cartilage degradation. Prolotherapy is a procedure where a natural irritant is injected into the soft tissue of an injured joint. Dexmedetomidine is a selective α2-adrenergic agonist with considerable sedative and analgesic actions.

Conditions

• Intraarticular
• Ozone
• Prolotherapy
• Dexmedetomidine
• Pain
• Knee Osteoarthritis

Interventions

Type	Name	Description
DRUG	Ozone	Patients received intraarticular ozone injection.
DRUG	Dextrose prolotherapy	Patients received intraarticular dextrose prolotherapy injection.
DRUG	Dexmedetomidine	Patients received intraarticular dexmedetomidine injection.

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-10-01
• Completion: 2023-10-01
• First posted: 2025-04-03
• Last updated: 2025-04-03

Locations

1 site across 1 country: Egypt