NCT06864026

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

A Phase 4, Prospective, Open-Label, Single-Arm Study to Assess the Effectiveness of Tirzepatide After Initiation of Ixekizumab in Adult Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice.

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Eli Lilly and Company · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

Conditions

• Psoriatic Arthritis
• Overweight or Obesity

Interventions

Type	Name	Description
DRUG	Tirzepatide	Administered SC

Timeline

• Start date: 2025-03-06
• Primary completion: 2027-11-01
• Completion: 2027-11-01
• First posted: 2025-03-07
• Last updated: 2026-02-10

Locations

55 sites across 2 countries: United States, Puerto Rico

Regulatory

• FDA-regulated drug study