Trials / Recruiting
RecruitingNCT06853951
Cardioprotection on Chemotherapy-Induced Cardiotoxicity
The Effect of Cardioprotective Medications on Chemotherapy-Induced Cardiotoxicity in Childhood Acute Leukemia
- Status
- Recruiting
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- Ain Shams University · Academic / Other
- Sex
- All
- Age
- 1 Year – 18 Years
- Healthy volunteers
- Not accepted
Summary
The aim of the present study is to evaluate the protective impact of cardioprotective medications on the chemotherapy- induced cardiotoxicity.
Detailed description
The goal of this interventional study is to evaluate the protective impact of Angiotensin-converting enzyme (ACE) inhibitors versus β-blockers on the cardiotoxicity profile of pediatric patients with acute leukemia. The impact is measured by evaluation of left ventricular ejection fraction (LVEF) by 2D echocardiography at baseline and at the end of Induction phase (42 days).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | ACE Inhibitors | 0.3 mg/kg/dose every 8 hours orally by either a caregiver or caring nurse. |
| DRUG | β -Blockers | 0.05 mg/kg/dose every 12 hours orally by either a caregiver or caring nurse. |
Timeline
- Start date
- 2023-07-18
- Primary completion
- 2025-03-30
- Completion
- 2025-07-18
- First posted
- 2025-03-03
- Last updated
- 2025-03-03
Locations
2 sites across 1 country: Egypt
Source: ClinicalTrials.gov record NCT06853951. Inclusion in this directory is not an endorsement.