NCT06836414

Lung Cancer Screening CT for Firefighters

Early Cancer Detection in Firefighters With Low-Dose Chest CT: A Community-Based Approach

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 35 Years
• Healthy volunteers: Accepted

Summary

Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as firefighting. This study aims to provide chest computed tomography (CT) scans to firefighters to determine the prevalence of lung cancer, other cancers detectable on CT chest, and lung diseases associated with increased cancer risk.

Detailed description

This is a single-group prospective interventional study and a community-based participatory project led by University of California, San Francisco and in close collaboration with the firefighter community in California. PRIMARY OBJECTIVE: I. Determine the prevalence of lung cancer, other cancers and cancer risk factors detectable on chest Computerized Tomography (CT) (Aim 1). II. Identify imaging and non-imaging predictors of lung cancer and other cancers detectable on chest CT. SECONDARY OBJECTIVE: I. Determine the prevalence of incidental findings on chest CT (Aim 1). II. Determine the risk factors for cancer development in firefighters (Aim 2). EXPLORATORY OBJECTIVES: I. Long term follow-up to determine the incidence of lung cancer and other cancers among firefighters. II. Develop a firefighter cancer imaging registry. OUTLINE: Participants will be administered a single, low dose chest CT to included participants and collect comprehensive demographic, clinical, and occupational data. Participants will be followed up at 1-2 months, for at least 1 year and up to 10 years to collect any follow-up imaging and biopsy results, if applicable.

Conditions

• Smoke Inhalation
• Exposure, Inhalation
• Exposure to Pollution
• Exposure Occupational
• Lung Diseases
• Lung Cancer
• Lung Diseases, Interstitial
• Occupational Exposure
• Occupational Lung Disease
• Interstitial Lung Disease

Interventions

Type	Name	Description
PROCEDURE	Low-dose Computerized tomography (CT) of Chest	Undergo CT for lung cancer screening
OTHER	Questionnaires	Participants will complete questionnaires on or before the day of the scan.
OTHER	Medical History	Medical history will be obtained in person and via medical record review

Timeline

• Start date: 2026-03-31
• Primary completion: 2035-12-31
• Completion: 2035-12-31
• First posted: 2025-02-20
• Last updated: 2026-04-13