NCT06825741

Brain Structural Abnormalities in Patients with Post-COVID-19 Headache

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: University of Pecs · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Introduction: The clinical manifestations of the COVID-19 pandemic are heterogeneous and may include various symptoms (gastrointestinal, musculoskeletal, neurological). Approximately 25% of patients report headache as a neurological symptom, making it the fifth most common symptom. These headaches may arise from structural brain changes associated with the infection. Purpose: This study aims to identify the structural abnormalities observed in brain MRI that correlate with chronic headaches in patients who had COVID-19 infection. Methods: The study included 30 patients with post-COVID-19 headaches and 30 control patients with no history of COVID-19. Demographic characteristics were analyzed using t-tests and chi-square tests. MRI findings were categorized into six types: cortical atrophy, white matter lesions, vascular lesions, lacunar lesions, vascular encephalopathy, and sinusitis. Differences in MRI findings between the two groups were evaluated using chi-square tests. Secondary outcomes included the analysis of symptoms accompanying headaches, diagnoses following MRI, and treatments applied.

Conditions

• COVID-19
• Headache
• MRI

Interventions

Type	Name	Description
OTHER	Observational Study - No intervention	This is an observational study evaluating brain structural abnormalities in post-COVID headache patients. No experimental intervention is applied.

Timeline

• Start date: 2020-09-01
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2025-02-13
• Last updated: 2025-02-17

Locations

1 site across 1 country: Hungary