Trials / Enrolling By Invitation
Enrolling By InvitationNCT06821646
Investigating the Brain's Physiological Responses in Depression and Autism, Using Transcranial Magnetic Stimulation and Electroencephalography
Social Cognition in Major Depression and Autism Spectrum Disorder: Cortical Excitatory-inhibitory Imbalance and Neuromechanism
- Status
- Enrolling By Invitation
- Phase
- —
- Study type
- Observational
- Enrollment
- 160 (estimated)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- 20 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
The goal of this observational study is to investigate the brain physiological responses in depression and autism. The main questions aim to answer are: 1. Comparing the ratios of cortical excitation and inhibition among four groups: autism group, autism with depression group, depression group, and normal control group using Transcranial magnetic stimulation and electroencephalography (TMS-EEG). This study explores the relationship between the ratios of cortical excitation and inhibition and the severity of clinical symptoms. 2. Comparing the brain inflammation among four groups: autism group, autism with depression group, depression group, and normal control group using Positron emission tomography (PET). This study investigates the relationship between brain inflammation and the severity of clinical symptoms. 3. The mutual influence between the severity of brain inflammation and Excitatory/inhibitory imbalance (E/I imbalance). Participants will receive clinical assessment, neurocognitive function tests, TMS-EEG, gamma oscillation, and PET examinations.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Positron Emission Tomography (PET) | 18F-N-((2-(2-(fluoro-18f)ethoxy)phenyl)methyl)-N-(4-phenoxy-3-pyridinyl) acetamide |
| DIAGNOSTIC_TEST | transcranial magnetic stimulation and electroencephalography(TMS-EEG) | single pulse and paired pulse |
Timeline
- Start date
- 2024-05-28
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
- First posted
- 2025-02-12
- Last updated
- 2026-01-12
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT06821646. Inclusion in this directory is not an endorsement.