Clinical Trials Directory

Trials / Recruiting

RecruitingNCT06820177

Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes

Prophylactic Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes: A Randomized Controlled Trial

Status
Recruiting
Phase
Phase 4
Study type
Interventional
Enrollment
276 (estimated)
Sponsor
University of California, San Diego · Academic / Other
Sex
Female
Age
18 Years
Healthy volunteers
Accepted

Summary

Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality. Tranexamic acid (TXA) is used commonly in obstetrics to prevent or manage intrapartum or postpartum hemorrhage and has been associated with decreased mortality and decreased blood loss at the time of birth. Some guidelines are recommending the use of TXA for both the prevention and management of bleeding for abortion care. However, there are currently no published studies assessing the association between TXA and bleeding outcomes for abortion procedures. This study will involve a randomized, placebo-controlled trial of pregnant patients aged 18 and older desiring dilation and evacuation (D\&E) for abortion or fetal demise at 18-24 weeks gestation. The primary aim is to determine whether prophylactic TXA has an effect on the need for additional interventions to control bleeding at the time of D\&E. The secondary aim is to determine whether prophylactic TXA has an effect on the mean quantitative procedural blood loss.

Conditions

Interventions

TypeNameDescription
DRUGTranexamic Acid1g tranexamic acid
DRUGPlacebo10 mL 0.9% normal saline

Timeline

Start date
2025-04-22
Primary completion
2026-05-01
Completion
2026-05-01
First posted
2025-02-11
Last updated
2025-08-01

Locations

2 sites across 1 country: United States

Regulatory

Source: ClinicalTrials.gov record NCT06820177. Inclusion in this directory is not an endorsement.