NCT06815679

Physiological Effects of Nebulized Salbutamol in Acute Respiratory Failure Patients on HFNC

The Physiological Effects of Nebulized Salbutamol in Patients With Acute Respiratory Failure During HFNC

• Status: Not Yet Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Università degli Studi di Ferrara · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective physiological interventional study that assess the feasibility and safety of administering salbutamol using a vibrating mesh nebulizer during HFNC in patients with acute hypoxemic respiratory failure (AHRF). We evaluate whether this method of salbutamol delivery can reduce inspiratory effort and improve global and regional lung ventilation in AHRF patients. To achieve this, the study will record and analyze the following: esophageal pressure (Pes) curves, global and regional tidal volumes, minute ventilation, and changes in global and regional lung ventilation assessed through Electrical Impedance Tomography (EIT).

Detailed description

To evaluate the patient's respiratory effort, the pressure-time product (PTPes) and the delta of Pes oscillations during inspiration (∆ Pes) will be obtained from the analysis of the Pes curve. Global and regional pulmonary tidal volumes will be evaluated with EIT.

Conditions

• Acute Respiratory Failure
• Pneumonia

Interventions

Type	Name	Description
DRUG	salbutamol 2.5 mg via vibrating mesh nebulizer (VMN)	To evaluate the patient's respiratory effort, the pressure-time product (PTPes) and the delta of Pes oscillations during inspiration (∆ Pes) will be obtained from the analysis of the Pes curve. Global and regional pulmonary tidal volumes will be evaluated with Electrical Impedance Tomography

Timeline

• Start date: 2025-03-01
• Primary completion: 2026-01-01
• Completion: 2026-07-01
• First posted: 2025-02-07
• Last updated: 2025-02-07

Locations

1 site across 1 country: Italy