NCT06814093

Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation

Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: A Retrospective Cohort Study Emulating the Target Trial

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,702 (actual)
• Sponsor: Xu jianmin · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the effectiveness of robotic surgery versus laparoscopic surgery in treating low rectal cancer. While robotic surgery has gained popularity, there is limited long-term evidence regarding its outcomes. By using real-world data from a specialized multicenter colorectal cancer database in Shanghai, China, this retrospective cohort study will emulate the target trial to evaluate whether robotic surgery offers advantages over laparoscopic surgery. Key factors such as disease-free survival, locoregional recurrence, circumferential margin positivity, and postoperative complications will be examined. The goal is to provide stronger, evidence-based support for the clinical use of robotic surgery in treating low rectal cancer.

Conditions

• Rectal Cancer

Interventions

Type	Name	Description
PROCEDURE	Robotic surgery	Robotic surgery for radical resection of middle and low rectal cancer
PROCEDURE	Laparoscopic surgery	Laparoscopic surgery for radical resection of middle and low rectal cancer

Timeline

• Start date: 2021-01-01
• Primary completion: 2025-04-30
• Completion: 2025-04-30
• First posted: 2025-02-07
• Last updated: 2025-05-09

Locations

1 site across 1 country: China