NCT06809972

Synovial Proliferation on Routine Ultrasound: Active or Inactive?

Synovial Proliferation on Routine Ultrasound: Active or Inactive? A Prospective Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 46 (estimated)
• Sponsor: Van Creveldkliniek · Academic / Other
• Sex: Male
• Age: 12 Years
• Healthy volunteers: Not accepted

Summary

There is cumulating evidence for the presence of non-observed or subclinical joint bleeding in patients with haemophilia. Early detection of active subclinical synovial proliferation would allow early intervention in order to prevent deterioration of joint health. Patients with subclinical (=non-observed) signs of synovial proliferation in knee(s), ankle(s) and/or elbow(s) will be invited to participate in this study to further characterize the synovial proliferation status (active or inactive) by means of physical examination, MRI, ultrasound and elastography. Synovial proliferation status will be monitored for a maximum period of 12 weeks, during which participants will also receive standard-of-care treatment, i.e. administration of optimized coagulation factor replacement therapy and prescription of the NSAID celecoxib (optional).

Detailed description

To be completed

Conditions

• Haemophilia
• Hemophilia A
• Hemophilia B

Interventions

Type	Name	Description
OTHER	Ultrasound imaging	Ultrasound, MRI and elastography to screen for and follow subclinical synovial changes in ankle, elbow and knee.

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-06-01
• Completion: 2025-12-21
• First posted: 2025-02-05
• Last updated: 2025-02-05

Locations

1 site across 1 country: Netherlands