NCT06786754

Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases

FIBROBLASTS AND THORACIC AORTIC ANEURYSMS: IN VITRO CHARACTERIZATION IN PATIENTS WITH MARFAN SYNDROME AND GENETIC AORTIC DISEASES

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 15 (estimated)
• Sponsor: IRCCS Policlinico S. Donato · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to characterise the phenotype of fibroblasts and to classify different mechanisms involved in the onset and progression of TAAD in syndromic and non-syndromic subjects in order to evaluate potential markers related to TAAD.

Detailed description

The aim of the study is to analyse cutaneous fibroblast properties in patients with thoracic aortic aneurysms (both syndromic and non-syndromic) to identify differences in molecular mechanisms in collagen turnover pathways compared to healthy controls in the general population.

Conditions

• Rare Diseases
• Thoracic Aortic Aneurysm (TAA)
• Marfan Syndrome

Timeline

• Start date: 2025-06-17
• Primary completion: 2025-12-01
• Completion: 2026-02-01
• First posted: 2025-01-22
• Last updated: 2025-09-10

Locations

1 site across 1 country: Italy