NCT06754319

Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 125 (estimated)
• Sponsor: Shanghai Mental Health Center · Academic / Other
• Sex: All
• Age: 7 Years – 17 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics, neuroimaging and electroencephalography (EEG), conducted before and after treatment with selective serotonin reuptake inhibitors (SSRIs). The results will be compared with those of pediatric OCD paitents comorbid with tic disorder (TD) and healthy controls. The findings are expected to further elucidate the potential pathogenesis of OCD, providing a theoretical basis for identifying novel clinical intervention targets and optimizing treatment strategies.

Conditions

• Obsessive-Compulsive Disorder
• Tic Disorder

Timeline

• Start date: 2024-08-24
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2024-12-31
• Last updated: 2024-12-31

Locations

1 site across 1 country: China