NCT06747871

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals With Opioid Use Disorder and Chronic Pain

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Conditions

• Chronic Pain
• Tobacco Use
• Opioid Substitution Treatment

Interventions

Type	Name	Description
BEHAVIORAL	Very Low Nicotine Cigarettes (VLNC)	Spectrum NRC 102/103 (nonmenthol/ menthol) cigarettes, which have a nicotine content of approximately 0.4 mg/g tobacco.
BEHAVIORAL	Normal Nicotine Cigarettes (NNC)	Spectrum NRC 600/601 (nonmenthol/ menthol) cigarettes, which have a nicotine content of approximately 15.8 mg/g tobacco.

Timeline

• Start date: 2025-04-15
• Primary completion: 2027-07-30
• Completion: 2027-07-30
• First posted: 2024-12-24
• Last updated: 2026-01-09

Locations

1 site across 1 country: United States