NCT06743373

Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults

Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults (CASCILS)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1. Does cannabis use and discontinuation impact sleep drive? 2. Does cannabis use and discontinuation impact light sensitivity and circadian phase?

Detailed description

Researchers will compare sleep, circadian phase, and light sensitivity within regular cannabis users before, during, and after a cannabis discontinuation protocol; researchers will also compare sleep, circadian phase, and light sensitivity between regular cannabis users and control non-cannabis users. Participants will: 1. Participate in a 1-week baseline period consisting of at-home monitoring (sleep diaries, actigraphy, EEG headband). 2. Participate in a 2-night lab visit consisting of circadian phase and light sensitivity assessment. 3. Participate in a 4-week cannabis discontinuation protocol (cannabis users only). 4. Participate in a second 2-night lab visit after the discontinuation protocol (cannabis users only).

Conditions

• Cannabis Use
• Sleep
• Circadian Rhythm

Interventions

Type	Name	Description
BEHAVIORAL	Cannabis Discontinuation	Cannabis-using participants will participate in an orientation session with a clinician and asked to abstain from cannabis use for four weeks, using established procedures for abstinence monitoring and reinforcement.

Timeline

• Start date: 2025-03-13
• Primary completion: 2029-01-31
• Completion: 2029-04-30
• First posted: 2024-12-19
• Last updated: 2026-04-06

Locations

1 site across 1 country: United States