NCT06735924

Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Non Alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (estimated)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Detailed description

Urinary oxalate excretion is derived from both dietary sources and endogenous synthesis. This study will use a low-oxalate controlled diet, repeat fasted urine collections and 24-hr urine collections on a low-oxalate diet, to determine the daily rate of endogenous oxalate synthesis in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Conditions

• MASLD
• Metabolic Dysfunction-Associated Steatotic Liver Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Low-oxalate fixed diet	Ingestion of a low-oxalate (\< 60 mg/day) , normal calcium (800-1200 mg/d) eucaloric diet for 5 days

Timeline

• Start date: 2023-04-26
• Primary completion: 2026-12-31
• Completion: 2027-12-31
• First posted: 2024-12-16
• Last updated: 2025-12-19

Locations

1 site across 1 country: United States