NCT06735235

Salivary Fluoride Clearance

Evaluation of Salivary Fluoride Clearance Following the Use of Three MFP-Containing Dentifrices

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Procter and Gamble · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a single-center, four-treatment, four-period crossover study. Over the course of the study, up to thirty qualified subjects will use four (4) study treatment products, one time each according to the randomization. Subjects will brush with 1.25g of the assigned study product at each visit. Subjects will provide saliva samples at baseline and at 2, 6, 12, and 30 minutes post-treatment. The F- concentrations in each saliva sample will be determined by ion chromatography

Conditions

• Caries

Interventions

Type	Name	Description
DRUG	0 ppm F	Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.
DRUG	250 ppm F as MFP	Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.
DRUG	1100 ppm as MFP	Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.
DRUG	2800 ppm F as MFP	Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.

Timeline

• Start date: 2021-07-14
• Primary completion: 2021-07-29
• Completion: 2021-07-29
• First posted: 2024-12-16
• Last updated: 2024-12-16

Locations

1 site across 1 country: United States