NCT06730516

Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate

Optic Nerve Head Perfusion Following Treatment with Latanoprost 0.005% Versus Brimionidin Tartrate 0.2% in Primary Open Angle Glaucoma: an Optical Coherence Tomography Angiography Study

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral primary open angle glaucoma equally divided into two groups with 28 patients in each group

Detailed description

This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral POAG equally divided into two groups with 28 patients in each group. The whole VD was increased and also increased in all four nasal, temporal, superior, and inferior quadrants around optic disc from the initial vessel density before treatment (p\<0.001) in both groups significantly with superior improvement in group (1) compared to group (2) that was statistically significant

Conditions

• Glaucoma

Interventions

Type	Name	Description
DRUG	Latanoprost (Xalatan)	latanoprost 0.005
DRUG	Brimonidine 0.2 %	Brimonidine0.2

Timeline

• Start date: 2024-06-24
• Primary completion: 2024-09-01
• Completion: 2024-10-01
• First posted: 2024-12-12
• Last updated: 2024-12-12

Locations

1 site across 1 country: Egypt