NCT06729580

Risk-Targeted Behavioural Activation for the Management of Treatment-Resistant Depression.

Risk-Targeted Behavioral Activation: a Novel Approach to the Management of Treatment-Resistant Depression.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 118 (actual)
• Sponsor: McGill University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Depression is the leading cause of disability worldwide. Major Depressive Disorder (MDD) is the most common diagnosis made for individuals seeking treatment for depression. Although a wide range of treatments have been developed for the treatment of MDD, a significant proportion of patients fail to respond. This study examined the effectiveness of a 10-week behavioural activation intervention for individuals with treatment-resistant depression.

Detailed description

Objective: The purpose of the present study was to examine the acceptability and impact of a standardized 10-week risk-targeted behavioral activation (RTBA) intervention as an augmentation strategy in the clinical management of treatment-resistant depression (TRD). Methods: The study sample consisted of 118 individuals with TRD, who were currently absent from work and referred to an occupational rehabilitation service. The RTBA intervention was a 10-week standardized program consisting of weekly visits with a trained clinician. The objectives of treatment included symptom reduction, resumption of important life activities (including return to work) and improvement in quality of life. Measures of depression, perceived injustice, and catastrophic thinking were completed pre-, mid- and post-treatment.

Conditions

• Treatment Resistant Depression (TRD)

Interventions

Type	Name	Description
BEHAVIORAL	Behavioural Activation	10-week standardized behavioural activation program.

Timeline

• Start date: 2022-01-05
• Primary completion: 2023-10-30
• Completion: 2023-10-30
• First posted: 2024-12-11
• Last updated: 2024-12-11

Locations

1 site across 1 country: Canada