NCT06723249

Stingless Bee Honey Augmentation in Major Depressive Disorders

The Effect of Stingless Bee Honey on BDNF, Oxidative Stress, Depressive Symptoms and Verbal Learning and Memory in Major Depressive Disorders: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Hospital Universiti Sains Malaysia · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if stingless bee honey can be an augmentation supplement in Major Depressive Disorder (MDD) in adults. It will also learn about the adverse effects of the honey. The main questions it aims to answer are: 1. Is there any effect of SBH on depressive symptoms between intervention and control groups in MDD? 2. Are there any effects of SBH on BDNF between intervention and control groups in MDD? 3. Are there any effects of SBH on oxidative stress between intervention and control groups in MDD? 4. Are there any effects of SBH on verbal learning and memory between intervention and control groups in MDD? There is no placebo. Participants will: Take stingless bee honey or nothing every day for 2 months Visit the clinic once every 4 weeks for checkups and tests Report adherence and adverse effects of stingless bee honey on a self-reported online questionnaires

Conditions

• Major Depressive Disorder (MDD)

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	stingless bee honey	Participants under intervention group will receive 20g of stingless bee honey in a packet form but participants under control group will not receive any stingless bee honey

Timeline

• Start date: 2024-12-15
• Primary completion: 2025-08-10
• Completion: 2025-08-10
• First posted: 2024-12-09
• Last updated: 2025-12-23

Locations

1 site across 1 country: Malaysia