NCT06719453

Prevalence of Alzheimer's Disease Pathology in the Community

Prevalence of Alzheimer's Disease Pathology in a Large Norwegian Population-based Cohort and Predictive Power of Plasma p-tau217 and NfL.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9,663 (actual)
• Sponsor: Helse Stavanger HF · Other Government
• Sex: All
• Age: 70 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to (I) study the proportion of people with Alzheimer's disease pathology in a large Norwegian population-based cohort of people aged 70 years or older and to (II) study longitudinal changes of Alzheimer's disease pathology in the same population over a 14 year period. The main aims are: * What is the proportion of people with Alzheimer's disease pathology, defined by elevated plasma p-tau217, in a large Norwegian population-based cohort of people aged 70 years or older. * What is the proportion of people with Alzheimer's disease pathology, defined by elevated plasma p-tau217, among those with normal cognition, mild cognitive impairment and dementia in a large Norwegian population-based cohort of people aged 70 years or older. * What is the association between plasma p-tau217 concentration and mild cognitive impairment or dementia 4, 10 and 14 years later, respectively. * What is the association between plasma NfL concentration and mild cognitive impairment or dementia 4, 10 and 14 years later, respectively. Data is used from The Nord-Trøndelag Health Study (HUNT) wave 3 (2006-2008) and 4 (2017 - 2019, also including HUNT AiT 2021-2023).

Conditions

• Dementia of Alzheimer Type
• Alzheimer Disease
• Mild Cognitive Impairment
• Pathology
• Biomarker in Early Diagnosis

Timeline

• Start date: 2006-10-03
• Primary completion: 2024-10-21
• Completion: 2024-10-21
• First posted: 2024-12-05
• Last updated: 2024-12-05