NCT06669026

The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

Therapeutic Efficacy of Local Vitamin D Drug as an Adjunct to Mechanical Debridement in the Treatment of Periodontitis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 25 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.

Conditions

• Periodontal Pocket

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel	Scaling and root debridement then inject gel in the pocket
DIETARY_SUPPLEMENT	vitamin D3 gel (regular non-nanoparticle form)	Scaling and root debridement then inject gel in the pocket
OTHER	Poly lactic-co-glycolic acid nanoparticles placebo gel	Scaling and root debridement then inject gel in the pocket
PROCEDURE	only mechanical debridement	Scaling and root debridement

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-03-15
• Completion: 2024-09-20
• First posted: 2024-11-01
• Last updated: 2024-11-01

Locations

1 site across 1 country: Egypt