Trials / Completed
CompletedNCT06668090
Bone Properties Following Exercise Induced Changes in Insulin Sensitivity in People With Type 2 Diabetes
Biochemical Bone Turnover Markers and Bone Mechanical Properties Following Exercise Induced Changes in Insulin Sensitivity in People With Type 2 Diabetes
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 42 (actual)
- Sponsor
- Aarhus University Hospital · Academic / Other
- Sex
- All
- Age
- 45 Years
- Healthy volunteers
- Not accepted
Summary
Diabetes mellitus type 2 is associated with low bone turnover and increased risk of bone fractures. Bone mineral density, however, is increased and cannot explain the increased fracture risk per se. The pathophysiology is not completely understood, but the decrease in bone turnover is believed to cause an accumulation of microcracks in bone tissue leading to bone fragility. The decrease in bone turnover may arise directly from insulin resistance or indirectly through formation of advanced glycation end-products. The main aim objective is to investigate how increases in insulin sensitivity following 12 weeks of moderate intensity bike exercise affect biochemical bone turnover markers and biomechanical bone properties in individuals with diabetes mellitus type 2.
Conditions
- Diabetes Mellitus, Type 2
- Insulin Resistance
- Bone Diseases, Metabolic
- Osteoporosis, Osteopenia
- Musculoskeletal Diseases
- Metabolic Disease
- Glucose Metabolism Disorders
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Moderate intensity bike exercise | Participants will do moderate intensity bike exercise for up to one hour thrice weekly for 12 weeks. |
Timeline
- Start date
- 2022-12-15
- Primary completion
- 2025-06-26
- Completion
- 2025-06-28
- First posted
- 2024-10-31
- Last updated
- 2025-08-14
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT06668090. Inclusion in this directory is not an endorsement.