NCT06667232

Evaluating Modulation Effects of Burst Stimulation Patterns Using SEEG

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Xuanwu Hospital, Beijing · Academic / Other
• Sex: All
• Age: 14 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The study aims to evaluate modulation effects of burst stimulation patterns via SEEG.

Detailed description

Our research group plans to conduct a study on patients with drug-resistant epilepsy who have SEEG electrodes implanted. The study will evaluate and compare the modulation effect of single-pulse electrical stimulation, paired electrical stimulation, stepwise electrical stimulation, and burst electrical stimulation via direct electrical stimulation using SEEG. The goal is to explore the focal and network modulation effect of distinct stimulation paradigms during the resting state and post-seizure state.

Conditions

• Epilepsy

Interventions

Type	Name	Description
OTHER	Single-pulse stimulation	Investigators use single-pulse electrical stimulations at 1Hz to elicit cortico-cortical evoked potentials
OTHER	Paired-pulse stimulation	The repetitive delivery of pairs of stimulation pulses is DES patten with a 5-50 ms interval between each pulse, constitutes repetitive paired-pulse stimulation.
OTHER	Stepwise frequency stimulation	Stepwise incremental stimulation ranging from 5 Hz to 145 Hz following a cyclic pattern.
OTHER	Burst stimulation	Burst stimulation pattern consisting of short bursts delivered once a second and an intraburst frequency of 50 Hz, 100 Hz, 150 Hz, 175 Hz and 200 Hz

Timeline

• Start date: 2025-01-18
• Primary completion: 2025-12-25
• Completion: 2026-12-01
• First posted: 2024-10-31
• Last updated: 2025-01-22

Locations

1 site across 1 country: China