NCT06662656

ED50 of Sufentanil for Intraoperative Analgesia

ED50 of Sufentanil with Dexmedetomidine Analgesia During Laparoscopic Cholecystectomy

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 26 (estimated)
• Sponsor: China International Neuroscience Institution · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

1. Sufentanil as an strong analgesic is used widespreadly during laparoscopic cholecystectomy. 2. Lower dosages of sufentanil facilitated with dexmedetomidine can offer enough analgesia effect. 3. The investigator are planning use the most classical method for determining the ED50 or half effective concentration of sufentanil facilitated with dexmedetomidine using sequential method, which is also called" up and down method" and" ladder method".

Detailed description

The concordance of the current research is that lower dosages of sufentanil facilitated with dexmedetomidine can offer enough analgesia effect through operation. However, the dosages of sufentanil used in various researches vary greatly of operations. Previous studies have shown that the amount of sufentanil required for intraoperative analgesia is smaller than that required while dexmedetomindine facilitated. Although the appropriate dosage of sufentanil required for operation can ensure the analgesic effect of operation, excessive dosage can cause severe choking during intubation, postoperative nausea and vomiting, hyperalgesia, and chronic postoperative pain. The investigator planning use the most classical method for determining the ED50 or half effective concentration of sufentainl combined with dexmedetomidine using sequential method, which is also called " up and down method" and " ladder method".

Conditions

• Laparoscopic Cholecystectomy
• Analgesics，Opioid

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-01-30
• Completion: 2025-01-30
• First posted: 2024-10-29
• Last updated: 2024-10-29

Locations

1 site across 1 country: China