NCT06661616

Cognitive Effects Associated With Hippocampal Neurogenesis Induced by ECT in the Treatment of Depression

Cognitive Effects Associated With Hippocampal Neurogenesis Induced by Electroconvulsive Therapy in the Treatment of Depression

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 87 (actual)
• Sponsor: Centre Hospitalier St Anne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Electroconvulsive therapy (ECT) is the treatment of choice for drug-resistant depression (30% of patients), or when there is a short-term risk to the patient's life. Despite its robust efficacy and rapid onset of action, its use is limited both by the limited range of treatment available and by the cognitive effects sometimes induced. The present study focuses on the links between the efficacy of ECT, its cognitive effects and the formation of new neurons in the hippocampus (hippocampal neurogenesis) associated with this treatment.

Conditions

• Major Depressive Disorder (MDD)
• Bipolar Disorder Depression

Timeline

• Start date: 2018-06-06
• Primary completion: 2024-05-14
• Completion: 2024-05-14
• First posted: 2024-10-28
• Last updated: 2024-10-28

Locations

1 site across 1 country: France