NCT06655025

The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

The Effects of Dexmedetomidine on Postoperative Cognitive Function and Neuron-Specific Enolase Levels in Open Heart Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

Detailed description

This randomized controlled study was conducted to evaluate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing elective open-heart surgery. Patients were randomly assigned into two groups: a dexmedetomidine group receiving intravenous dexmedetomidine infusion during surgery and a control group receiving normal saline infusion as placebo in addition to standard anesthesia. Postoperative cognitive function was assessed using the Mini-Mental State Examination (MMSE). Serum neuron-specific enolase (NSE) levels were measured as a biomarker of neuronal injury. Intraoperative depth of anesthesia was monitored using the bispectral index (BIS). The aim of the study was to investigate whether dexmedetomidine administration could reduce postoperative cognitive dysfunction and neuronal injury in patients undergoing cardiac surgery.

Conditions

• Cardiac Surgery
• Postoperative Cognitive Dysfunction
• Neurologic Manifestations

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Dexmedetomidine infusion during open heart surgery

Timeline

• Start date: 2023-10-08
• Primary completion: 2024-09-08
• Completion: 2024-10-08
• First posted: 2024-10-23
• Last updated: 2026-03-11

Locations

1 site across 1 country: Egypt