NCT06650150

Respiratory Muscle Strength and Exercise Capacity in Smokers

Comparative Study on Respiratory Muscle Strength and Exercise Capacity in Smokers With COPD, PRISm and Pre-COPD

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 150 (actual)
• Sponsor: Muğla Sıtkı Koçman University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This cross-sectional study aims to evaluate the respiratory muscle strength and physical capacity of symptomatic adult smokers in Muğla. The study population will be the patients who were admitted to the pulmonary outpatient clinic of Muğla Training and Research Hospital between July 2024 and December 2024. The primary outcome is the proportion of individuals with Maximum Inspiratory Pressure (MIP) below 80%. Secondary outcomes include the 6-Minute Walk Test (6MWT) distance, Maximum Expiratory Pressure (MEP), and COPD Assessment Test (CAT) scores. Smokers will be categorized into COPD, PRISm, and Pre-COPD groups. The study will adjust for BMI as a key confounder and assess the modifying effects of gender, smoking habits, and age. Ethical approval and informed consent will be obtained, with data analysis focusing on descriptive statistics, comparative analysis, and regression models to understand the impact of smoking on respiratory health.

Conditions

• COPD - Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	maximal inspiratory pressure	maximal inspiratory pressure (mip) will be measured with a specific device
DIAGNOSTIC_TEST	maximal expiratory pressure	MEP will be measured with a specific device
DIAGNOSTIC_TEST	6 minute walk test	6mwt will be done by a phsyotherapist

Timeline

• Start date: 2024-10-20
• Primary completion: 2025-07-20
• Completion: 2025-07-20
• First posted: 2024-10-21
• Last updated: 2025-08-08

Locations

1 site across 1 country: Turkey (Türkiye)