NCT06613321

Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy

Impact of Lung Hyperinflation on the Response to Pulmonary Vasodilator Therapy in Patients with Pulmonary Hypertension (PH) Associated with Chronic Obstructive Pulmonary Disease (COPD).

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 47 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD). The study will include all patients from the hospital, followed for pulmonary hypertension associated with COPD under vasodilator therapy between 2015 and 2021.

Detailed description

The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD). The study will include all patients from the hospital, followed for PH associated with COPD under vasodilator therapy between 2015 and 2021. It will evaluate patients' lung hyperinflation according to the RV/TLC ratio and their response to treatment.

Conditions

• Copd
• Hypertension, Pulmonary
• Hyperdistention

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Respiratory function tests before introduction of vasodilator therapy	Respiratory function tests before introduction of vasodilator therapy with evaluation of the RV/TLC ratio.
DIAGNOSTIC_TEST	3 month follow up evaluation of response to treatment.	Follow up of patients at least 3 months after introduction of vasodilator therapy to determine response to treatment or absence of response.

Timeline

• Start date: 2023-08-01
• Primary completion: 2024-03-25
• Completion: 2024-03-25
• First posted: 2024-09-25
• Last updated: 2024-09-25

Locations

1 site across 1 country: France