NCT06601608

Efficacy of Locally Delivered Rosemary Extract Gel in Management of Periodontitis

Efficacy of Locally Delivered Rosemary Extract Gel as an Adjunct to Non-Surgical Periodontal Therapy in Management of Periodontitis (A Randomized Controlled Clinical Trial With Microbiological Analysis)

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Rosemary extract is known for its antibacterial, anti-inflammatory and anti-oxidant properties that make it a promising therapeutic aid as a local delivery drug in deep periodontal pockets in adjunct to non-surgical periodontal therapy in management of periodontitis. These properties are due to the high content of phenolic compounds such as carnosic acid, urolic acid, rosmarinic acid or chlorogenic acid. Rosemary extract was previously investigated and proved its effectiveness against periodontopathogens in-vitro. Thus, its selected for this study to be administered in a gel form to assess its efficacy in management of periodontitis.

Detailed description

Forty eight patients with deep periodontal pockets more than 5 mm will be randomly assigned into 2 equal groups. The test group will receive the rosemary extract gel in adjunct to non-surgical periodontal therapy, while the control group will receive placebo gel. Clinical evaluation of the clinical parameters including probing depth, gingival index, plaque index and clinical attachment level will be recorded. Microbiological analysis using PCR test will be performed using perio-papers.

Conditions

• Periodontitis (Stage 3)
• Periodontal Pocket

Interventions

Type	Name	Description
DRUG	Herbal therapy	rosemary extract gel is used for the first time as a local drug delivery as an adjunct to non-surgical periodontal therapy in management of stage III periodontitis patients.
DRUG	Placebo Drug	a placebo gel will be applied in deep pockets (\>5mm) in stage III periodontitis patients as an adjunct to non-surgical periodontal therapy

Timeline

• Start date: 2024-10-20
• Primary completion: 2025-08-02
• Completion: 2025-10-11
• First posted: 2024-09-19
• Last updated: 2026-04-13

Locations

1 site across 1 country: Egypt