NCT06594406

The Effect of Oral Bifidobacterium on Exogenous Creatine Absorption in Adult Subjects

The Therapeutic Effects of Combining Bifidobacterium With Creatine on Depression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: Zhujiang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this clinical trial is to learn if Bifidobacterium has antidepressant-like effects by enhancing creatine absorption in adults. The main questions to be answered are Does Bifidobacterium combined with creatine have better antidepressant effects? Does Bifidobacterium enhance exogenous creatine uptake? Researchers will compare bifidobacterium combined with creatine with placebo to see if bifidobacterium combined with creatine has antidepressant effects. Participants will: Take bifidobacterium, creatine or placebo every day for 4 weeks. Keep a diary of their symptoms and collect blood samples.

Conditions

• Depression

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creatine	The dosing schedule of creatine administration is 3 g daily for 4 weeks, and administration of a placebo.
DIETARY_SUPPLEMENT	Bifidobacterium and creatine	The dosing schedule of creatine administration is 3 g daily for 4 weeks. In parallel, the dosing schedule of bifidobacterium administration is 200 million colony-forming units (CFU) /day for 4 weeks.
DIETARY_SUPPLEMENT	Placebo	Administration of creatine placebo and bifidobacterium placebo for 4 weeks,

Timeline

• Start date: 2024-10-10
• Primary completion: 2025-05-30
• Completion: 2025-06-27
• First posted: 2024-09-19
• Last updated: 2025-08-03

Locations

1 site across 1 country: China