NCT06590935

Endocrine and Exocrine Secretory Function Alterations After Moderately Severe and Severe Acute Pancreatitis

Prospective Cohort Study on Endocrine and Exocrine Secretory Function Alterations After Moderately Severe and Severe Acute Pancreatitis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Shanghai Changzheng Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (PPDM-A). The main questions it aims to answer are: 1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after acute pancreatitis of different etiologies the same? 2. Are alterations in endocrine and exocrine secretory function in patients with acute pancreatitis associated with all-round outcomes? All patients with acute pancreatitis have been given the standardized treatment for the condition. Investigators will compare the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after acute pancreatitis of different etiologies in patients with moderately severe (MSAP) and severe acute pancreatitis (SAP) to explore the association between alterations in endocrine and exocrine secretory function and all-round outcomes.

Detailed description

Investigators will prospectively collect data from patients with moderately severe (MSAP) and severe acute pancreatitis (SAP) in participant centers.

Conditions

• Acute Pancreatitis (AP)
• Diabetes Mellitus

Timeline

• Start date: 2024-10-08
• Primary completion: 2026-09-01
• Completion: 2026-09-01
• First posted: 2024-09-19
• Last updated: 2025-02-21

Locations

1 site across 1 country: China