Trials / Completed
CompletedNCT06562309
Fecal Microbiota and Monocyte Trained Immunity in CHD Patients With Different hsCRP
Fecal Microbiota and Monocyte Trained Immunity in Patients With Coronary Heart Disease and Different Level of High-sensitivity C-reactive Protein (hsCRP)
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (actual)
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Academic / Other
- Sex
- All
- Age
- 35 Years – 75 Years
- Healthy volunteers
- —
Summary
This single-center study enrolled patients aged 35-75 years who were diagnosed with unstable angina (UA), and had at least one of the three major coronary arteries with a ≥ 50% reduction in lumen diameter by angiographic visual estimation. Patients were all recruited at the Department of Cardiology, Union Hospital, Wuhan, Hubei Province, China. Feces and blood samples were collected on admission were used promptly for ex vivo studies.
Detailed description
This single-center study enrolled patients aged 35-75 years who were diagnosed with unstable angina (UA), and had at least one of the three major coronary arteries with a ≥ 50% reduction in lumen diameter by angiographic visual estimation. Patients were all recruited at the Department of Cardiology, Union Hospital, Wuhan, Hubei Province, China. Exclusion criteria included acute myocardial infarction, prior myocardial infarction, malignancies, auto-immune or auto-inflammatory diseases, or ongoing infection. Feces and blood samples were collected on admission were used promptly for ex vivo studies. the aim of the study is to investigate whether the fecal microbiota and peripheral blood monocytes in patients with coronary heart disease at different levels of inflammation are associated with the level of inflammation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | take feces and blood samples from patients | this study does not involve any intervention |
Timeline
- Start date
- 2021-05-11
- Primary completion
- 2024-04-30
- Completion
- 2024-07-15
- First posted
- 2024-08-20
- Last updated
- 2024-08-20
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06562309. Inclusion in this directory is not an endorsement.