NCT06550154

Association Between Oral Lichen Planus and Thyroid Disease

Association Between Oral Lichen Planus and Thyroid Disease: A Cross-sectional Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: University of Barcelona · Academic / Other
• Sex: All
• Age: 29 Years – 94 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to determine the prevalence of thyroid disease in adults with oral lichen planus (OLP) treated at the Dental Hospital of the University of Barcelona (HOUB), and to evaluate the association between OLP and thyroid disease. Secondly, to assess the association between OLP and other comorbidities, including arterial hypertension, diabetes mellitus type 2, dyslipidemia, anxiety, and depression. The main question it aims to answer is: Do people with OLP have a significant risk of developing thyroid disorders compared to people without OLP?

Detailed description

A cross-sectional study was conducted to investigate a total of 120 participants, 60 patients with oral lichen planus and 60 patients without the history of OLP as a control group, attending at the Dental Hospital of the University of Barcelona (HOUB). The personal medical history of thyroid disease, demographic information (age and gender) and other comorbidities history information, were collected in both groups, and obtained through the GESDEN® healthcare software (Gesden G5, Infomed - Henry Schein®, New York, United States), in addition to the paper medical records (biopsy report). Data were analyzed using χ² test and simple binary logistic regression models with the SPSS® statistical software, version 29.0.2.0 for Windows (SPSS, Illinois, United States).

Conditions

• Oral Lichen Planus
• Thyroid Disease

Interventions

Type	Name	Description
OTHER	Data collection	Participants were identified by reviewing electronic medical records. Medical history information of thyroid disease and associated medication were collected in both groups, as well as a history of other comorbidities such as diabetes mellitus type 2, arterial hypertension, dyslipidemia, anxiety, and depression. Cases and controls were matched by age and sex.

Timeline

• Start date: 2023-12-13
• Primary completion: 2024-04-17
• Completion: 2024-04-22
• First posted: 2024-08-12
• Last updated: 2024-08-12

Locations

1 site across 1 country: Spain