NCT06543407

Harm Reduction for Smokers With Mental Illness

Harm Reduction for Smokers With Mental Illness: RCT of E-cigarette Provision With or Without Behavioral Support to Boost Switching

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Dartmouth-Hitchcock Medical Center · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation treatment, and to examine self-regulation (using e-cigs instead of cigarettes to cope with stress/distress and self-efficacy) as a potential mechanism for behavior change from SWITCH IT

Conditions

• Tobacco Dependence

Interventions

Type	Name	Description
BEHAVIORAL	SWITCH IT	Behavioral support for switching, 7-10 sessions with SWITCH IT coach delivered during the first 8 weeks of the study. SWITCH IT participants will also have the opportunity to receive supported "field trips" to explore e-cigarette options based on availability, cost, and preferences during week 4 and week 6.
OTHER	E-cig Provision Only	Provision of e-cigarettes (NJOY) based on combusible use for the first 8 weeks of the study.

Timeline

• Start date: 2024-10-01
• Primary completion: 2027-12-31
• Completion: 2028-03-31
• First posted: 2024-08-09
• Last updated: 2026-01-15

Locations

2 sites across 1 country: United States