Trials / Withdrawn
WithdrawnNCT06537063
Detection of G-quadruplex DNA Methylation in Cancer
Early Diagnosis Value of G-quadruplex DNA Methylation in Patients with Cancer
- Status
- Withdrawn
- Phase
- —
- Study type
- Observational
- Enrollment
- 0 (actual)
- Sponsor
- Zhongnan Hospital · Academic / Other
- Sex
- All
- Age
- 42 Years
- Healthy volunteers
- Accepted
Summary
This study aims to evaluate the early diagnosis value of G-quadruplex DNA methylation in patients with cancer.
Detailed description
Global DNA hypomethylation is a hallmark of most cancers that occurs early during oncogenesis. We would like to investigate whether cancer-specific transcription factor binding to DNA G-quadruplex drives DNA hypomethylation in cancer. In this observational study, we would like to clarify whether DNA hypomethylation around G-quadruplex loci in cell-free DNA could be detected in early-stage cancer patients from healthy donors with high sensitivity and specificity.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | G4 DNAm test | Detection of DNA methylation (DNAm) around G-quadruplex loci in cell-free DNA from blood. |
Timeline
- Start date
- 2024-04-30
- Primary completion
- 2024-09-30
- Completion
- 2024-12-30
- First posted
- 2024-08-05
- Last updated
- 2025-01-07
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06537063. Inclusion in this directory is not an endorsement.