NCT06518785

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to examine the effects of Low-Intensity Focused Ultrasound (LIFU) on brain activity in patients with alcohol use disorder.

Detailed description

This is a single-center, double-blind, controlled, randomized, complete block, 2-period crossover pilot trial. The study will assess target engagement of the ventral striatum after LIFU in patients with alcohol use disorder using resting state and task-based functional magnetic resonance imaging (fMRI).

Conditions

• Alcohol Use Disorder

Interventions

Type	Name	Description
DEVICE	Low Intensity Focused Ultrasound	An inhibitory LIFU protocol that allows suppression of neuronal activity in the basal ganglia and thalamus will be used.

Timeline

• Start date: 2025-01-07
• Primary completion: 2030-09-01
• Completion: 2030-09-01
• First posted: 2024-07-24
• Last updated: 2025-09-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study