NCT06506513

Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease

Targeting Myosteatosis Though Physical Exercise to Treat Metabolic Dysfunction-associated Steatotic Liver Disease

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.

Detailed description

In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.

Conditions

• Metabolic Dysfunction-associated Steatotic Liver Disease

Interventions

Type	Name	Description
OTHER	High-intensity interval training	High-intensity interval training
OTHER	Moderate intensity exercise training	Moderate intensity exercise training
OTHER	Low intensity exercise training	Low intensity exercise training

Timeline

• Start date: 2024-10-01
• Primary completion: 2025-10-01
• Completion: 2026-09-01
• First posted: 2024-07-17
• Last updated: 2024-07-17

Locations

2 sites across 1 country: Belgium