NCT06482164

The THINK Study Incidence of Neurotrophic Keratopathy)

The THINK Study (Testing Hypoesthesia and the Incidence of Neurotrophic Keratopathy)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Research Insight LLC · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study purpose is to evaluate corneal sensitivity in patients that have Stage 1 Neurotrphic Keratopathy (NK). Identifying patients with Stage 1 NK, may predict those who will in the future require rhNGF for optimal visual performance.

Detailed description

The purpose of this study is to evaluate corneal sensitivity in a cross-section of patients with signs of dry eye disease (DED), correlating findings against clinical parameters relating to the severity of disease and impact on quality of vision. Identifying those patients with Stage 1 Neurotrophic Keratopathy (NK), i.e. those with corneal staining and reduced sensitivity, may predict those who will in the future require rhNGF for optimal visual performance.

Conditions

• Dry Eye

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Dry Eye Disease	Corneal sensitivity in patients who also have dry eye.

Timeline

• Start date: 2024-04-18
• Primary completion: 2024-08-07
• Completion: 2024-08-07
• First posted: 2024-07-01
• Last updated: 2026-03-31

Locations

1 site across 1 country: United States