NCT06467513

To Investigate the Effect of Esketamine Hydrochloride on Pulmonary Complications

To Investigate the Effect of Esketamine on Hemodynamics and Postoperative Pulmonary Complications in Patients Undergoing Heart Valve Replacement Surgery

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 102 (estimated)
• Sponsor: Zhang XIao Mei · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study was to evaluate the effect of esketamine on intraoperative hemodynamics in patients with heart valve replacement and to mitigate postoperative pulmonary complications

Detailed description

After being informed of the study and potential risks, all patients who gave written informed consent will undergo pre-operative screening to determine eligibility for study enrollment. Before operation, eligible patients were randomly divided into esketamine group (0.2mg/kg, intraoperative pump), esketamine group (0.4mg/kg, intraoperative pump) and blank control group (physiological salt pump) in a double-blind way at a ratio of 1:1:1.

Conditions

• Heart Diseases
• Heart Valve Diseases

Interventions

Type	Name	Description
DRUG	Esketamine hydrochloride injection	The low dose esketamine hydrochloride group was given 0.2mg/kg at induction of anesthesia, the high dose esketamine hydrochloride group was given 0.4mg/kg at induction of anesthesia, and the blank control group was not given Esketamine hydrochloride injection at induction of anesthesia.

Timeline

• Start date: 2024-01-01
• Primary completion: 2025-05-01
• Completion: 2025-05-01
• First posted: 2024-06-21
• Last updated: 2024-06-21

Locations

1 site across 1 country: China