NCT06463262

Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

In this study the investigators will study the effects of neoadjuvant radiation therapy (RT), in the form of either proton therapy or stereotactic body radiation therapy (SBRT), on the Circulating tumor DNA (ctDNA), radiographic changes and radiomics, and the validity of these findings will be compared using the current gold standard- pathologic findings. The purpose of this work is to explore whether the biomarkers may be used diagnostically to better understand radiographic changes following RT. The investigators hypothesize that ctDNA levels in combination with imaging biomarkers identified through radiomics will be a sensitive and specific tool for predicting histopathologic response to RT.

Conditions

• Chordoma of Spine
• Chordoma of Skull Base
• Chordoma of Sacrum

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ctDNA	the effects of neoadjuvant RT, in the form of either proton therapy or SBRT, on the ctDNA

Timeline

• Start date: 2024-06-14
• Primary completion: 2029-07-01
• Completion: 2031-07-01
• First posted: 2024-06-17
• Last updated: 2025-10-24

Locations

2 sites across 1 country: United States