NCT06456229

Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery

Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery (PICCS-1)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 162 (estimated)
• Sponsor: National University Hospital, Singapore · Academic / Other
• Sex: All
• Age: 21 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

There is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. One metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus, time to defecation, as well as postoperative abdominal distension (PMID:37373843). More broadly in gastrointestinal surgery, a meta-analysis of 21 randomised controlled trials similarly affirmed the speedier recovery of gastrointestinal function after surgery when probiotics were administered (PMID: 35231076). In spite of these advantages, the routine use of probiotics perioperatively for colorectal cancer surgery is not performed in Singapore. We therefore seek to perform a trial to investigate whether probiotic administration perioperatively may reduce post operative ileus rates.

Conditions

• Colorectal Cancer
• Ileus Postoperative
• Flatus
• Diet, Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Nestle Isocal	Nestle Isocal
DIETARY_SUPPLEMENT	Nestle Boost Optimum	Nestle Boost Optimum

Timeline

• Start date: 2024-07-01
• Primary completion: 2025-05-01
• Completion: 2025-05-01
• First posted: 2024-06-13
• Last updated: 2024-06-13

Locations

1 site across 1 country: Singapore