NCT06451016

Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Frontier Medical and Dental College, Abbotabad · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Introduction: A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD). Methodology: A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.

Conditions

• Graves Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D supplements	70 mcg/day (equal to 2800 IU) of cholecalciferol
DIETARY_SUPPLEMENT	Placebo	Matching Placebo

Timeline

• Start date: 2021-01-01
• Primary completion: 2023-12-30
• Completion: 2024-01-15
• First posted: 2024-06-10
• Last updated: 2024-06-14

Locations

2 sites across 1 country: Pakistan