NCT06408571

Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 3,900 (estimated)
• Sponsor: Zhongnan Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was explored.

Detailed description

1\. Clinical data of patients with RVO and DR Were retrospectively studied to analyze their pathogenesis. 2. Metabolomic studies were conducted on body fluids (intraocular fluid and peripheral blood) of patients with RVO and DR And control group to find out the differences and find new targets for the prevention and treatment of RVO and DR.

Conditions

• Metabolomics; Retinopathy; Etiology

Interventions

Type	Name	Description
OTHER	etiology	As an important part of systems biology, metabolomics mainly detects various metabolites in the sample. Different from nucleic acids, proteins and other biological macromolecules, the relative molecular weight of these metabolites is small, generally within 1000Da, such as amino acids, carboxylic acids, carbohydrates, alcohols, amines, lipids and other special substances. Through qualitative and quantitative analysis of all endogenous low molecular weight metabolites before and after pathophysiology or gene modification stimulation, metabolomics reveals the essential characteristics of life activities and metabolism of the body, and provides guidance for exploring the pathogenesis, early diagnosis, treatment and prognosis of diseases.

Timeline

• Start date: 2023-09-07
• Primary completion: 2024-10-30
• Completion: 2024-12-30
• First posted: 2024-05-10
• Last updated: 2024-05-10

Locations

1 site across 1 country: China